Presynaptic dopamine modulation by stimulant self-administration
نویسندگان
چکیده
منابع مشابه
dopamine modulation by stimulant self - administration
1. Abstract 2. Introduction 3. Nucleus accumbens 4. Stimulant actions 4.1. Cocaine and amphetamine 4.2. In vitro brain slice voltammetry 4.3. Microdialysis 4.4. Differences in dopamine signaling within the nucleus accumbens 4.5. Time of onset of cocaine and other dopamine transporter inhibitors 5. Neurochemical consequences of cocaine and amphetamine self-administration 5.1. Reduced responsivit...
متن کاملAdaptations of Presynaptic Dopamine Terminals Induced by Psychostimulant Self-Administration
A great deal of research has focused on investigating neurobiological alterations induced by chronic psychostimulant use in an effort to describe, understand, and treat the pathology of psychostimulant addiction. It has been known for several decades that dopamine neurotransmission in the nucleus accumbens is integrally involved in the selection and execution of motivated and goal-directed beha...
متن کاملStimulant Self-Administration
Stimulants such as cocaine and the amphetamines are widely abused due to their rewarding effects. Much of what we know about drug abuse and drug reward comes from research involving stimulants, and much of this research involves using drug self-administration as an animal model of drug abuse. In this chapter, the example of stimulant self-administration is used to illustrate: (1) the basic meth...
متن کاملIntermittent cocaine self-administration produces sensitization of stimulant effects at the dopamine transporter.
Previous literature investigating neurobiological adaptations following cocaine self-administration has shown that high, continuous levels of cocaine intake (long access; LgA) results in reduced potency of cocaine at the dopamine transporter (DAT), whereas an intermittent pattern of cocaine administration (intermittent access; IntA) results in sensitization of cocaine potency at the DAT. Here, ...
متن کاملPresynaptic dopamine in schizophrenia.
Presynaptic dopamine (DA) transmission has been measured in schizophrenia using different paradigms aimed at providing estimates of the integrity or the activity of the presynaptic dopaminergic neuron. RESEARCHERS HAVE MEASURED: (1) DA synthesis capacity with [(18) F]DOPA, a measure of the activity of dopa decarboxylase, (2) DA release with studies measuring the impact of a DA releasing stimula...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Frontiers in Bioscience
سال: 2013
ISSN: 1945-0516,1945-0524
DOI: 10.2741/s371